Archive \ Volume.11 2020 Issue 1

Aphrodisiac Herbal therapy for Erectile Dysfunction

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  1. Research Scholar Department of Foods and Nutrition, Government Home Science College, Panjab University, Chandigarh, India.
  2. Research Scholar, Department of Foods and Nutrition, Institute of Home Science, Bundelkhand University, Jhansi, Uttar Pradesh, India.

Abstract

Erectile dysfunction (ED) or male impotence is described as an inability to maintain penile erection primarily endothelial and neuronal dysfunction which is partly characterized by decreased production of nitric oxide (NO). Male impotence can be caused by androgen deficiency in aging men, atherosclerosis, diabetes mellitus, spinal cord injury, high level of cholesterol, hypertension, prostate surgery, prostate and heart disease, penis anatomical deformity, social and psychological conditions as unhappy marital relationship, depression, and stress. Aphrodisiac is a drink or food that arouse sexuality. It can be categorized into three groups according to their action mode as follows: increase sexual pleasure substances, increase libido substances (arousal, sexual desire), and increase sexual potency (erection effectiveness). Various extracts of medicinal plants and orally active drugs such as vardenafil, sildenafil, and tadalafil are used to increase arterial blood flow for treating (ED) in southwest Asia. Hence, this paper review focuses on medicinal plants used as aphrodisiacs for scientific validation and management of erectile dysfunction (ED).



How to cite:
Vancouver
Goel B, Maurya NK. Aphrodisiac Herbal therapy for Erectile Dysfunction. Arch Pharm Pract. 2020;11(1):1-6.
APA
Goel, B., & Maurya, N. K. (2020). Aphrodisiac Herbal therapy for Erectile Dysfunction. Archives of Pharmacy Practice, 11(1), 1-6.

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References
  1. Nayak BN, Buttar HS. Herbal therapy for men with erectile dysfunction. Current Research: Cardiology. 2015;2(1):30-4.
  2. Kałka D, Gebala J, Rusiecki L, Smoliński R, Dulanowski J, Rusiecka M, Biełous-Wilk A, Pilecki W, Womperski K, Zdrojowy R. Relation of Postexercise Reduction of Arterial Blood Pressure and Erectile Dysfunction in Patients with Coronary Heart Disease. The American journal of cardiology. 2018;122(2):229-34.
  3. Mobley DF, Khera M, Baum N. Recent advances in the treatment of erectile dysfunction. Postgraduate medical journal. 2017;93(1105):679-85.
  4. Kałka D, Gebala J, Rusiecki L, Smoliński R, Dulanowski J, Rusiecka M, Biełous-Wilk A, Pilecki W, Womperski K, Zdrojowy R. Relation of Postexercise Reduction of Arterial Blood Pressure and Erectile Dysfunction in Patients with Coronary Heart Disease. The American journal of cardiology. 2018;122(2):229-3
  5. Hackett G, Kirby M, Wylie K, Heald A, Ossei-Gerning N, Edwards D, Muneer A. British Society for Sexual Medicine guidelines on the management of erectile dysfunction in men—2017. The journal of sexual medicine. 2018;15(4):430-57.
  6. Claudino MA, Priviero FB, Teixeira CE, De Nucci G, Antunes E, Zanesco A. Improvement in relaxation response in corpus cavernosum from trained rats. Urology. 2004;63(5):1004-8.
  7. B. Sargia, B. Singh, N. Gupta, LK Gahlot, T. Gulati, Y. Hasija. MED-PDB: An online database of medicinal plants. J Adv Pharm Edu Res 2018;7(4):204-20
  8. Pucot JR, Manting MME, Demayo CG., Ethnobotanical Plants used by Selected Indigenous Peoples of Mindanao, the Philippines as Cancer Therapeutics, Pharmacophore, 2019; 10(3), 61-69.
  9. Morilla LJG, Demayo CG. Medicinal Plants Used by Traditional Practitioners in Two Selected Villages of Ramon Magsaysay, Zamboanga Del Sur”, Pharmacophore, 2019; 10(1), 84-92.
  10. Munir A, Malik SI, Aslam S, Mehmood A, Amjad S, Malik KA, Younis M, Shah AH, Shah GM, Medicinal plants are effective inhibitors of type I and II diabetes, Pharmacophore, 2018; 9(5), 1-7.
  11. Kanjikar AP. On Anti-Diabetic Potential of Phyto-nanoparticles Comparison with Hormonal Therapy and Medicinal Plants, International Journal of Pharmaceutical and Phytopharmacological Research, 2019; 9(1), 103-1
  12. Trudel G, Goldfarb MR. Marital and sexual functioning and dysfunctioning, depression and anxiety. Sexologies. 2010;19(3):137-42.
  13. Rastrelli, G., Guaraldi, F., Reismann, Y., Sforza, A., Isidori, A. M., Maggi, M., & Corona, G. Testosterone Replacement Therapy for Sexual Symptoms. Sexual Medicine Reviews   2019; 7(3), 464–475.
  14. Saxena A, Prakash P, Porwal M, Sissodia N, Sharma P. Erectile dysfunction: A review and herbs used for its treatment. International Journal. 2012; 6(2):109-117.
  15. Alwaal A, Breyer BN, Lue TF. Normal male sexual function: emphasis on orgasm and ejaculation. Fertility and sterility. 2015;104(5):1051-60.
  16. Singh R, Singh S, Jeyabalan G, Ali A, Semwal A. Sexual dysfunction: An overview and medicinal plant used for treatment of sexual dysfunction. Crit Rev Pharm Sci. 2012;1(2):9-24.
  17. Shiri R, Koskimäki J, Hakama M, Häkkinen J, Huhtala H, Tammela TL, Auvinen A. Effect of life-style factors on incidence of erectile dysfunction. International Journal of Impotence Research. 2004;16(5):389.
  18. Polland A, Davis M, Zeymo A, Venkatesan K. Comparison of correlated comorbidities in male and female sexual dysfunction: findings from the third national survey of sexual attitudes and lifestyles (Natsal-3). The journal of sexual medicine. 2018;15(5):678-86.
  19. Seo DY, Lee SR, Kwak HB, Park H, Seo KW, Noh YH, Song KM, Ryu JK, Ko KS, Rhee BD, Han J. Exercise training causes a partial improvement through increasing testosterone and eNOS for erectile function in middle-aged rats. Experimental gerontology. 2018;108:131-8.
  20. Jansakul C, Yorsin S, Naphatthalung J, Tachanaparugse K, Changwichai K, Chootip K, Ingkaninan K. Relaxant mechanism of Eulophia macrobulbon ethanolic extract and 1-(4΄-hydroxybenzyl)-4, 8-dimethoxyphenanthrene-2, 7-diol on human corpus cavernosum. Functional Foods in Health and Disease. 2019;9(5):328-40.
  21. Moncada I, Martinez-Salamanca J, Ruiz-Castañe E, Romero J. Combination therapy for erectile dysfunction involving a PDE5 inhibitor and alprostadil. International journal of impotence research. 2018;30(5):203-8.
  22. Ziegelmann MJ, Levine LA. A Modern Approach to the Clinical Evaluation of Peyronie’s Disease in the Era of Collagenase. The journal of sexual medicine. 2019;16(4):483-8.
  23. Song J, Sharman T. Yohimbine Induced Type II Myocardial Injury: An Underrecognized and Dangerous Adverse Effect. American Journal of Medical Case Reports. 2019;7(11):271-3.
  24. Yang X, Hu G, Lv L, Liu T, Qi L, Huang G, You D, Zhao J. Regulation of P-glycoprotein by Bajijiasu in vitro and in vivo by activating the Nrf2-mediated signalling pathway. Pharmaceutical biology. 2019;57(1):184-92.
  25. Yarnell E. Herbs for erectile dysfunction. Alternative and Complementary Therapies. 2015;21(6):276-83.
  26. Rowland DL, Tai W. A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions. Journal of Sex &Marital Therapy. 2003;29(3):185-205.
  27. Sener TE, Tavukcu HH, Atasoy BM, Cevik O, Kaya OT, Cetinel S, Dagli Degerli A, Tinay I, Simsek F, Akbal C, Butticè S. Resveratrol treatment may preserve the erectile function after radiotherapy by restoring antioxidant defence mechanisms, SIRT1 and NOS protein expressions. International journal of impotence research. 2018;30(4):179.
  28. Li H, He WY, Lin F, Gou X. Panax notoginseng saponins improve erectile function through attenuation of oxidative stress, restoration of Akt activity and protection of endothelial and smooth muscle cells in diabetic rats with erectile dysfunction. Urologia internationalis. 2014;93(1):92-9.
  29. Pratap SA, Rajender S. Potent natural aphrodisiacs for the management of erectile dysfunction and male sexual debilities. Frontiers in Bioscience. 2012;4:167-80.
  30. Valentová K, Ulrichová J. Smallanthus sonchifolius and Lepidium meyenii-prospective Andean crops for the prevention of chronic diseases. Biomed Papers. 2003;147(2):119-
  31. Gonzales GF, Gonzales C, Gonzales-Castaneda C. Lepidium meyenii (Maca): a plant from the highlands of Peru–from tradition to science. Complementary Medicine Research. 2009;16(6):373-80.
  32. Shin YS, Zhao C, Zhang LT, Park JK. Current status and clinical studies of oriental herbs in sexual medicine in Korea. The world journal of men's health. 2015;33(2):62-72.
  33. Wei X, Reardon D, Wu Y, Sun JH. Emerald ash borer, Agrilus planipennis Fairmaire (Coleoptera: Buprestidae), in China: a review and distribution survey. Acta entomologica sinica. 2004;47(5):679-85.
  34. Chun JN, Cho M, So I, Jeon JH. The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms. Fitoterapia. 2014;97:224-33.
  35. Ye BH, Kim EJ, Baek SE, Choi YW, Park SY, Kim CD. α-Isocubebene modulates vascular tone by inhibiting myosin light chain phosphorylation in murine thoracic aorta. The Korean Journal of Physiology & Pharmacology. 2018;22(4):437-45.
  36. Melnyk JP, Marcone MF. Aphrodisiacs from plant and animal sources—A review of current scientific literature. Food Research International. 2011;44(4):840-50.
  37. Kim HK, Choi BR, Bak YO, Zhao C, Lee SW, Jeon JH, So I, Park JK. The role of capillarisin from Artemisia capillaris on penile erection. Phytotherapy Research. 2012;26(6):800-5.
  38. Lee JH, Chiang SY, Nam D, Chung WS, Lee J, Na YS, Sethi G, Ahn KS. Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases. Cancer letters. 2014;345(1):140-8.
  39. Yang L, Chen Q, Wang F, Zhang G. Antiosteoporotic compounds from seeds of Cuscuta chinensis. Journal of ethnopharmacology. 2011;135(2):553-60.
  40. Sumalatha K, Kumar SA, Lakshmi SM. Review on natural aphrodisiac potentials to treat sexual dysfunction. Int J Pharm Ther. 2010; 1(1), 6-14
  41. Ryu JH, Kang D. Physicochemical properties, biological activity, health benefits, and general limitations of aged black garlic: A review. Molecules. 2017;22(6):919.
  42. Li H, Jiang H, Liu J. Traditional Chinese medical therapy for erectile dysfunction. Translational andrology and urology. 2017;6(2):192-198
  43. Zhang H, Wang XF, Cao D, Niu JF, Wang ZZ. The complete chloroplast genome sequence of Angelica Tsinlingensis (Apioideae). Mitochondrial DNA Part B. 2018;3(2):480-481.
  44. Ye M, Zhao F, Ma K, Zhou K, Huang W-J, Ma Y, et al. Effect of HongJing I in Treating Erectile Function and Regulating RhoA Pathway in a Rat Model of Bilateral Cavernous Nerve Injury. Evidence-Based Complementary and Alternative Medicine [Internet]. Hindawi Limited; 2019;2019:1–11.
  45. Yeh KY, Wu CH, Tai MY, Tsai YF. Ginkgo biloba extract enhances noncontact erection in rats: the role of dopamine in the paraventricular nucleus and the mesolimbic system. Neuroscience. 2011;189:199-206.
  46. Rojas P, Ruiz-Sánchez E, Rojas C, Ögren SO. Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinsonism in mice. Neuroscience. 2012;223:246-57.
  47. Chiou WF, Huang YL, Chen CF, Chen CC. Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum. Planta medica. 2001;67(03):282-4.
  48. Rahimi R, Ghiasi S, Azimi H, Fakhari S, Abdollahi M. A review of the herbal phosphodiesterase inhibitors; future perspective of new drugs. Cytokine. 2010;49(2):123-9.
  49. Hashim S, Bakht T, Marwat KB, Jan A. Medicinal properties, phytochemistry and pharmacology of Tribulus terrestris L.(Zygophyllaceae). Pakistan Journal of Botany. 2014;46(1):399-404.
  50. Kamenov Z, Fileva S, Kalinov K, Jannini EA. Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction—a prospective, randomized, double-blind, placebo-controlled clinical trial. Maturitas. 2017;99:20-26.
  51. Tuntiyasawasdikul S, Limpongsa E, Jaipakdee N, Sripanidkulchai B. A monolithic drug-in-adhesive patch of methoxyflavones from Kaempferia parviflora: In vitro and in vivo evaluation. International Journal of Pharmaceutics [Internet]. Elsevier BV; 2015;478(2):486–95
  52. Liu J, Tian J, Li J, Azietaku JT, Zhang BL, Gao XM, Chang YX. The in‐capillary DPPH‐capillary electrophoresis‐the diode array detector combined with reversed‐electrode polarity stacking mode for screening and quantifying major antioxidants in Cuscuta chinensis Lam. Electrophoresis. 2016;37(12):1632-9.
  53. Alamgir ANM. Pharmacognostical Botany: Classification of Medicinal and Aromatic Plants (MAPs), Botanical Taxonomy, Morphology, and Anatomy of Drug Plants. Therapeutic Use of Medicinal Plants and Their Extracts: Volume 1 [Internet]. Springer International Publishing; 2017;177–293.
  54. Zhao ZK, Yu HL, Liu B, Wang H, Luo Q, Ding XG. Antioxidative mechanism of Lycium barbarum polysaccharides promotes repair and regeneration following cavernous nerve injury. Neural regeneration research. 2016;11(8):1312.
  55. Luo Q, Li Z, Huang X, Yan J, Zhang S, Cai YZ. Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats. Life sciences. 2006;79(7):613-21.
  56. Selvi SK, Vinoth A, Varadharajan T, Weng CF, Padma VV. Neferine augments therapeutic efficacy of cisplatin through ROS-mediated non-canonical autophagy in human lung adenocarcinoma (A549 cells). Food and chemical toxicology. 2017;103:28-40.
  57. Stein RA, Schmid K, Bolivar J, Swick AG, Joyal SV, Hirsh SP. Kaempferia parviflora ethanol extract improves self-assessed sexual health in men: A pilot study. Journal of integrative medicine. 2018;16(4):249-54.
  58. Yang Y, Yao Z, Wang G, Hou J, Liu X. Panax notoginseng saponins protects H9c2 cardiomyocytes against hypoxia/reoxygenation injury via activating the JAK2/STAT3 pathway. Int J Clin Exp Med. 2019;12(7):8461-71.
  59. Li H, He WY, Lin F, Gou X. Panax notoginseng saponins improve erectile function through attenuation of oxidative stress, restoration of Akt activity and protection of endothelial and smooth muscle cells in diabetic rats with erectile dysfunction. Urologia internationalis. 2014;93(1):92-9.
  60. Knox M, Vinet R, Fuentes L, Morales B, Martínez JL. A Review of Endothelium-Dependent and-Independent Vasodilation Induced by Phytochemicals in Isolated Rat Aorta. Animals. 2019;9(9):623-32.
  61. Ghasemi M. Nitric oxide: Antidepressant mechanisms and inflammation. Advances in pharmacology (San Diego, Calif.). 2019;86:121-52.
  62. Gao JX, Li Y, Zhang HY, He XL, Bai AS. Lycopene ameliorates erectile dysfunction in streptozotocin-induced diabetic rats. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2012;67(3):256-9.
  63. Tian L, Xin ZC, Liu WJ, Yang YM, Liu G, Chen L, Fu J, Wang LL. Effects of icariin on the erectile function and expression of nitrogen oxide synthase isoforms in corpus cavernosum of arterigenic erectile dysfunction rat model. Zhonghua yi xue za zhi. 2004;84(11):954-7.
  64. Zhou F, Xin H, Liu T, Li GY, Gao ZZ, Liu J, Li WR, Cui WS, Bai GY, Park NC, Xin ZC. Effects of icariside II on improving erectile function in rats with streptozotocin‐induced diabetes. Journal of andrology. 2012;33(5):832-44.
  65. Feng XT, Qin CB, Leng J, Tang QL, Shi H, Zhai LN, Li SL. Yidiyin, a Chinese herbal decoction, improves erectile dysfunction in diabetic patients and rats through the NO-cGMP pathway. Bioscience, biotechnology, and biochemistry. 2012;76(2):257-63.
  66. Chye PL. Traditional Asian folklore medicines in sexual health. Indian Journal of Urology. 2006;22(3):241.
  67. Cui T, Kovell RC, Brooks DC, Terlecki RP. A urologist's guide to ingredients found in top-selling nutraceuticals for men's sexual health. The journal of sexual medicine. 2015;12(11):2105-17.
  68. https://www.newscientist.com/article/dn14825-horny-goat-weed-could-be-better-than-viagra/ accessed on 18/10/2019.
  69. McDonald TJ, Perry MH, Jones AG, Donohoe M, Salzmann MB, O'Connor J. A novel case of a raised testosterone and LH in a young man. Clinica Chimica Acta. 2011;412(21-22):1999-2001.
  70. Mehraban F, Jafari M, Toori MA, Sadeghi H. Effects of date palm pollen (Phoenix dactylifera L.) and Astragalus ovinus on sperm parameters and sex hormones in adult male rats. Iranian Journal of Reproductive Medicine. 2014;12(10):705-12.
  71. Akunna GG, Saalu CL, Ogunmodede OS, Ogunlade B, Bello AJ. Aqueous extract of date fruit (Phoenix dactylifera) protects testis against atrazine-induced toxicity in rat. World J Life Sci Med Res. 2012;2(2):100-8.
  72. Dickson C. Food, medicinal and other plants from the 15th century drains of Paisley Abbey, Scotland. Vegetation history and Archaeobotany. 1996;5(1-2):25-31.

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