Introduction: Health care providers such as social security hospitals, as one of the most important social organizations, play a major role in improving the health status of the community and providing health services. Hence, identifying organizational corruption and illness and eliminating them is crucial. Objective: The main objective of this study was to present a model for the treatment of systemic (organizational) illnesses in the social security hospitals of Isfahan province. Methodology: This study was a sequential type of mixed-exploratory study. The objective of this study was to design and formulate a model according to the designed model criteria and through a meta-synthesis technique. Using a case study method and semi-structured interviews with experts and professors, the research model criteria were developed. In the quantitative section, a descriptive-survey method (Delphi technique) was used and a researcher-made tool was used to measure its external effectiveness. Results: Based on a qualitative model, four categories of organizational illness, including management, financial, administrative, and technical were identified. Considering the current situation, the relevant solutions were also identified. Based on the fuzzy Delphi technique, all factors were confirmed with a score of above 0.7. Discussion and Conclusion: In this study, management, financial, administrative and technical factors were identified as the main causes of corruption in social security hospitals in Isfahan province. Eliminating these factors could partly improve the economic performance of the organization and restore knowledge storage. Based on the obtained results, it is recommended for hospital planners, authorities, and policymakers to pay attention to concerns about increasing corruption in the social security hospital, especially in units and people who have high economic power.