Modern medicine cannot do without the use of new technologies, including nanotechnology. They make it possible to achieve significant improvements in the diagnosis and treatment of various diseases, as well as increase the effectiveness of prevention. In particular, in recent years, more and more attention has been paid to the use of silver, zinc, and copper nanoparticles in medicine. They have unique properties, such as antimicrobial, antiviral, and anti-inflammatory effects, which allows them to be used to fight various infections and inflammatory processes. This scientific paper examines the effect of medical treatment of a fresh wound with preparations based on silver nanoparticles and an alloy of copper and zinc in the example of laboratory rats. Visual observation of the wound healing process was carried out, as well as morphological and hematological parameters of blood serum were studied. During the experiment, it was found that the treatment of a fresh wound with a preparation based on silver nanoparticles led to the fastest wound healing. And treatment with a preparation based on copper and zinc alloy nanoparticles significantly reduced the recovery time. The toxicological safety of the use of both drugs has been proven.
1. Taher SS, Al-Kinani KK, Hammoudi ZM, Mohammed Ghareeb M. Co-surfactant effect of polyethylene glycol 400 on microemulsion using BCS class II model drug. J Adv Pharm Educ Res. 2022;12(1):63-9.
2. Nakagawa N, Odanaka K, Ohara H, Kisara S. Evaluation of drug information literacy gained through e-learning to prepare students for practical pharmacy experience. J Adv Pharm Educ Res. 2021;11(4):111-5.
3. Herman TF, Bordoni B. Wound Classification. 2022. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
4. Shpichka A, Butnaru D, Bezrukov EA, Sukhanov RB, Atala A, Burdukovskii V, et al. Skin tissue regeneration for burn injury. Stem Cell Res Ther. 2019;10(1):94. doi:10.1186/s13287-019-1203-3
5. Oryan A, Alemzadeh E, Moshiri A. Burn wound healing: present concepts, treatment strategies, and future directions. J Wound Care. 2017;26(1):5-19. doi:10.12968/jowc.2017.26.1.5
6. Wong She RB, Gibran NS. Burn Wound Bed Management. J Burn Care Res. 2023;44(Suppl_1): S13-S8. doi:10.1093/jbcr/irac128
7. Palackic A, Jay JW, Duggan RP, Branski LK, Wolf SE, Ansari N, et al. Therapeutic Strategies to Reduce Burn Wound Conversion. Medicina (Kaunas). 2022;58(7):922. doi:10.3390/medicina58070922
8. Nazareth C, Pereira S. A review on chiral stationary phases for separation of chiral drugs. Int J Pharm Phytopharmacol Res. 2020;10(3):77-91.
9. Maheswary T, Nurul AA, Fauzi MB. The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review. Pharmaceutics. 2021;13(7):981. doi:10.3390/pharmaceutics13070981
10. Daeschlein G. Antimicrobial and antiseptic strategies in wound management. Int Wound J. 2013;10 Suppl 1(Suppl 1):9-14. doi:10.1111/iwj.12175
11. Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The History of Nanoscience and Nanotechnology: From Chemical–Physical Applications to Nanomedicine. Molecules. 2020;25(1):112. doi:10.3390/molecules25010112
12. Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine. Molecules. 2019;25(1):112. doi:10.3390/molecules25010112
13. Girija AR, Balasubramanian S, Cowin AJ. Nanomaterials-based Drug Delivery Approaches for Wound Healing. Curr Pharm Des. 2022;28(9):711-26. doi:10.2174/1381612828666220328121211
14. Mendes C, Thirupathi A, Corrêa MEAB, Gu Y, Silveira PCL. The Use of Metallic Nanoparticles in Wound Healing: New Perspectives. Int J Mol Sci. 2022;23(23):15376. doi:10.3390/ijms232315376
15. Dukueva MZ, Abdullayeva GR, Kagirov GM, Babaev ZR, Shapovalov LO, Danenko JI. Biological Significance and Toxicological Properties of Iron, Selenium, and Iodine. Pharmacophore. 2022;13(4):112-8. doi:10.51847/LYLLukyZLJ
16. Sergeevna SM, Efimovna LE, Irina K. Pharmaceutical consulation as a basis for drug care continuity. Pharmacophore. 2020;11(4):76-82.
17. AlRuwaili NS, Mohammad AA, Alnathir HF, Alfeheid MH, Alshammari NN. Illicit Drugs Addiction Among Patients with Chronic Diseases: Simple Review Article. Pharmacophore. 2022;13(3):81-5.
18. Abbasi E, Milani M, Fekri Aval S, Kouhi M, Akbarzadeh A, Tayefi Nasrabadi H, et al. Silver nanoparticles: Synthesis methods, bio-applications, and properties. Crit Rev Microbiol. 2016;42(2):173-80. doi:10.3109/1040841X.2014.912200
19. Blinov AV, Nagdalian AA, Povetkin SN, Gvozdenko AA, Verevkina MN, Rzhepakovsky IV, et al. Surface-Oxidized Polymer-Stabilized Silver Nanoparticles as a Covering Component of Suture Materials. Micromachines. 2022;13(7):1105. doi:10.3390/mi13071105
20. Pino P, Bosco F, Mollea C, Onida B. Antimicrobial Nano-Zinc Oxide Biocomposites for Wound Healing Applications: A Review. Pharmaceutics. 2023;15(3):970. doi:10.3390/pharmaceutics15030970
21. Batool M, Khurshid S, Qureshi Z, Daoush WM. Adsorption, antimicrobial, and wound healing activities of biosynthesized zinc oxide nanoparticles. Chem Pap. 2021;75:893-907. doi:10.1007/s11696-020-01343-7
22. Blinov AV, Kachanov MD, Gvozdenko AA, Nagdalian AA, Blinova AA, Rekhman ZA, et al. Synthesis and Characterization of Zinc Oxide Nanoparticles Stabilized with Biopolymers for Application in Wound-Healing Mixed Gels. Gels. 2023;9(1):57. doi:10.3390/gels9010057
23. Xu VW, Nizami MZI, Yin IX, Yu OY, Lung CYK, Chu CH. Application of Copper Nanoparticles in Dentistry. Nanomaterials. 2022;12(5):805. doi:10.3390/nano12050805
24. Lyashenko EN, Uzbekova LD, Polovinkina VV, Dorofeeva AK, Ibragimov S-US-u, Tatamov AA, et al. Study of the Embryonic Toxicity of TiO2 and ZrO2 Nanoparticles. Micromachines. 2023;14(2):363. doi:10.3390/mi14020363
25. Carobene A, Braga F, Roraas T, Sandberg S, Bartlett WA. A systematic review of data on biological variation for alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transferase. Clin Chem Lab Med. 2013;51(10):1997-2007. doi:10.1515/cclm-2013-0096
26. Díaz Martínez AE, Alcaide Martín MJ, González-Gross M. Basal Values of Biochemical and Hematological Parameters in Elite Athletes. Int J Environ Res Public Health. 2022;19(5):3059. doi:10.3390/ijerph19053059
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