Metoclopramide hydrochloride is used for the treatment of emesis. It is also used for chemotherapy and radiotherapy, and migraine induced nausea and vomiting. The objective of the study was the comparative assessment of different brands of metoclopramide hydrochloride. Different physiochemical tests according to USP were performed using different instruments. Scanning electron microscopy was also performed. Methanol, (Merck, Darmstadt, Germany) was used as regents. A reported method was utilized for the assay and dissolution studies. The results in weight variation test and friability ed within the pharmacopeia specified limits. The strength of the branded tablets was 6.15±0.18 to 8.77±0.38 kg. The disintegration time was within 4.1±0.52 to 7.11± 0.39 min. FT-IR and SEM analysis depicted complete compatibility between the active and excipients. The assay and dissolution results showed determination at 272 and 309 nm with USP limits. The spectrophotometric methods assess the quality and efficacy of tablets effectively, hence the evaluation provides the evidence to choose the brands for treatment.
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