Objectives: The impact of hydroxypropylmethyl cellulose (HPMC K 100M) alone and in combination with the guar gum, xanthan gum and gum tragacanth on the release of the diclofenac sodium matrix tablets were evaluated.
Materials and Methods: The granules were prepared using wet granulation method and compressed into tablets using different ratio of drug and gum ratio. The physical properties of the tablets were within acceptable pharmacopeial limits. The release profiles of the matrix tablets were evaluated in-vitro, using USP dissolution apparatus II (paddle method). Results: The formulations containing HPMC K 100M drug ratio 1:1.3 and 1:1.6 and formulations containing HPMC, gum and drug with different ratio also sustained the release of diclofenac sodium for 12 hours. The mechanism of drug release from the matrix tablets was studied using Zero order, First order, Higuchi and Korsmeyer's models using regression coefficient method. The stability of the selected formulations was evaluated at 40°C and 70% RH for 6 months.
Conclusions: HPMC K100M alone and in combination with natural gums as the retarding material retarded the release up to 12 hours and showed little deviation from the theoretical release pattern.