Liver fibrosis is a serious disease characterized by the excessive formation of connective tissue in an organ with a predisposition to cirrhosis. Understanding the mechanisms underlying the development of liver fibrosis is an important step towards the development of new methods for the diagnosis and treatment of this disease. Long non-coding RNAs (lncRNAs) are a class of RNAs that have been shown to play an important role in the pathogenesis of liver fibrosis and may be potential targets for new therapeutic approaches. This article reviews the role and pathogenetic mechanisms of lncRNAs in liver fibrosis, studies related to the identification of these mechanisms, as well as the prospects for using lncRNAs as diagnostic markers and therapeutic targets. The identification and study of these lncRNAs may provide new opportunities for the development of innovative approaches to the diagnosis and treatment of liver fibrosis. Further research is needed to fully understand the molecular mechanisms associated with lncRNAs and liver fibrosis and to determine their potential as biomarkers and therapeutic targets.
1. Parola M, Pinzani M. Liver fibrosis: Pathophysiology, pathogenetic targets, and clinical issues. Mol Aspects Med. 2019;65:37-55. doi:10.1016/j.mam.2018.09.002
2. Mortazavizadeh SM, Rafatmagham S, Tabatabaie F, Hakimizad R, Hashemipour SMA. Frequency distribution and ten-year survival rate of patients with different malignant liver lesions in Iran. J Adv Pharm Educ Res. 2022;12(2):71-5.
3. Almalki GH, Rabah S, Said Arafa NM, Bahshwan SM. Immunohistochemical evaluation of the euphorbia inarticulata extract on liver and kidney tissues in hepatocellular carcinoma rats. Pharmacophore. 2022;13(2):33-40.
4. Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet. 2009;10(3):155-9. doi:10.1038/nrg2521
5. Hombach S, Kretz M. Non-coding RNAs: Classification, Biology, and Functioning. Adv Exp Med Biol. 2016;937:3-17. doi:10.1007/978-3-319-42059-2_1
6. Mekereș GM, Buhaș CL, Tudoran C, Csep AN, Tudoran M, Manole F, et al. The practical utility of psychometric scales for the assessment of the impact of posttraumatic scars on mental health. Front Public Health. 2023;11:1103714
7. Ransohoff JD, Wei Y, Khavari PA. The functions and unique features of long intergenic non-coding RNA. Nat Rev Mol Cell Biol. 2018;19(3):143-57. doi:10.1038/nrm.2017.104
8. Panni S, Lovering RC, Porras P, Orchard S. Non-coding RNA regulatory networks. Biochim Biophys Acta Gene Regul Mech. 2020;1863(6):194417. doi:10.1016/j.bbagrm.2019.194417
9. Mahpour A, Mullen AC. Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy. JHEP Rep. 2020;3(1):100177. doi:10.1016/j.jhepr.2020.100177
10. Dumitru M, Vrinceanu D, Banica B, Cergan R, Taciuc IA, Manole F, et al. Management of Aesthetic and Functional Deficits in Frontal Bone Trauma. Medicina. 2022;58(12):1756.
11. Andrei CS, Vaida L, Bungau S, Todor BI. Clinical and Biological Correlations in Toxoplasma gondii Infection in HIV Immune Suppressed Persons. Iran J Public Health. 2015;44(7):1012-3.
12. Liu C, Hou X, Mo K, Li N, An C, Liu G, et al. Serum non-coding RNAs for diagnosis and stage of liver fibrosis. J Clin Lab Anal. 2022;36(10):e24658. doi:10.1002/jcla.24658
13. Hanson A, Wilhelmsen D, DiStefano JK. The Role of Long Non-Coding RNAs (lncRNAs) in the Development and Progression of Fibrosis Associated with Nonalcoholic Fatty Liver Disease (NAFLD). Noncoding RNA. 2018;4(3):18. doi:10.3390/ncrna4030018
14. Gil N, Ulitsky I. Regulation of gene expression by cis-acting long non-coding RNAs. Nat Rev Genet. 2020;21(2):102-17. doi:10.1038/s41576-019-0184-5
15. Quinn JJ, Chang HY. Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 2016;17(1):47-62. doi:10.1038/nrg.2015.10
16. Zhang L, Hu J, Meshkat BI, Liechty KW, Xu J. LncRNA MALAT1 Modulates TGF-β1-Induced EMT in Keratinocyte. Int J Mol Sci. 2021;22(21):11816. doi:10.3390/ijms222111816
17. Song Y, Guo NH, Zheng JF. LncRNA-MALAT1 regulates proliferation and apoptosis of acute lymphoblastic leukemia cells via miR-205-PTK7 pathway. Pathol Int. 2020;70(10):724-32. doi:10.1111/pin.12993
18. Cai W, Xu H, Zhang B, Gao X, Li S, Wei Z, et al. Differential expression of lncRNAs during silicosis and the role of LOC103691771 in myofibroblast differentiation induced by TGF-β1. Biomed Pharmacother. 2020;125:109980. doi:10.1016/j.biopha.2020.109980
19. Gupta D, Bhattacharjee O, Mandal D, Sen MK, Dey D, Dasgupta A, et al. CRISPR-Cas9 system: A new-fangled dawn in gene editing. Life Sci. 2019;232:116636. doi:10.1016/j.lfs.2019.116636
20. Sahadevan S, Sekaran T, Schwarzl T. A Pipeline for Analyzing eCLIP and iCLIP Data with Htseq-clip and DEWSeq. Methods Mol Biol. 2022;2404:189-205. doi:10.1007/978-1-0716-1851-6_10
21. Ghafouri-Fard S, Abak A, Talebi SF, Shoorei H, Branicki W, Taheri M, et al. Role of miRNA and lncRNAs in organ fibrosis and aging. Biomed Pharmacother. 2021;143:112132. doi:10.1016/j.biopha.2021.112132
22. Fu Y, Wang W, Li X, Liu Y, Niu Y, Zhang B, et al. LncRNA H19 interacts with S-adenosylhomocysteine hydrolase to regulate LINE-1 Methylation in human lung-derived cells exposed to Benzo[a]pyrene. Chemosphere. 2018;207:84-90. doi:10.1016/j.chemosphere.2018.05.048
23. Rohilla S, Awasthi A, Kaur S, Puria R. Evolutionary conservation of long non-coding RNAs in non-alcoholic fatty liver disease. Life Sci. 2021;264:118560. doi:10.1016/j.lfs.2020.118560
24. Marconi GD, Fonticoli L, Rajan TS, Pierdomenico SD, Trubiani O, Pizzicannella J, et al. Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration, and Organ Fibrosis. Cells. 2021;10(7):1587. doi:10.3390/cells10071587
Copyright © 2024 Archives of Pharmacy Practice. Authors retain copyright of their article if they are accepted for publication.
Developed by Archives of Pharmacy Practice
