Archive \ Volume.15 2024 Issue 1

Glucomannan Ameliorates Hepatic Lipid Metabolism and Glucose Homeostasis in Rat Models Fed a High-Fat Diet

Roaa M. Alreemi , Khadija S. Radhi , Taqwa Bushnaq , Ohud Saleh , Reem S. Alazragi*✉
  1. Department of Biochemistry, College of Science, University of Jeddah, Jeddah 21959, Saudi Arabia.
  2. Department of Food Science and Nutrition, College of Science, Taif University, Taif 21944, Saudi Arabia.

Abstract

This work was conducted to investigate the effects of glucomannan extracted from konjac (KGM) on high-fat diet (HFD)-)-induced lipid metabolic abnormalities and dysglycaemia and explore its possible mechanisms. Sixty adult male albino rats (Sprague-Dawley) were separated into five groups: G1 (control) fed a basal fat diet (BFD); G2, fed a high-fat modified diet containing 20% fat (HFD); and G3, G4, and G5, fed an HFD supplemented with three levels of KGM (1, 5, and 10 g/100 g diet, respectively). Results showed that rats fed HFDs developed hepatic glucose and lipid abnormalities. Glucomannan administration normalized hepatic glucose metabolism in HFD-fed rats with low fasting blood glucose. KGM may postpone obesity, diabetes, and associated consequences as a dietary intervention.  To sum up, supplementing rats with 10 g/100g dietary Glucomannan improves blood lipid levels, lipid metabolism in the liver, and glucose regulation. This suggests that KGM could be supplied in the future as a potential anti-hyperglycaemic and antilipidemic dietary supplement.


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Vancouver
Alreemi RM, Radhi KS, Bushnaq T, Saleh O, Alazragi RS. Glucomannan Ameliorates Hepatic Lipid Metabolism and Glucose Homeostasis in Rat Models Fed a High-Fat Diet. Arch Pharm Pract. 2024;15(1):121-6. https://doi.org/10.51847/IUaZmNExfl
APA
Alreemi, R. M., Radhi, K. S., Bushnaq, T., Saleh, O., & Alazragi, R. S. (2024). Glucomannan Ameliorates Hepatic Lipid Metabolism and Glucose Homeostasis in Rat Models Fed a High-Fat Diet. Archives of Pharmacy Practice, 15(1), 121-126. https://doi.org/10.51847/IUaZmNExfl

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