Abstract
The skin is at the interface between the organism and the environment, realizing the element of unity that the totality of the organs and systems in the human body has. Through its structure and position on the human body, the skin has a main role in the economy of the whole organism; it also has an aesthetic role. The objective of this study is to assess the embryological origin, anatomical and histological structure of the skin. The skin consists of the epidermis, which is of ectodermal origin, and the dermis, which is of mesodermal origin. The most important functions of the skin are the protection, thermoregulation, control of fluid loss, immunity, and sensory perception. The source of the cutaneous vessels comes directly from arterial sources otherwise, as terminal branches of muscular vessels. Various specialized anatomical structures are placed in the skin to receive different stimuli: free nerve endings, Merkel cells, Meissner corpuscles, Pacinian corpuscles, Krause bulbs, Ruffini corpuscles, proprioceptors for cold and heat. Various post-lesion changes in the skin can affect daily activities in the sense of alienation and isolation from significant people, and in some situations, can lead to job loss, neurotic disorders, and negative social consequences.
References
- Khavkin J, Ellis DA. Aging skin: Histology, physiology, and pathology. Facial Plast Surg Clin North Am. 2011;19(2):229-34. doi:10.1016/j.fsc.2011.04.003deleted
- Căiță GA, Maghiar T, Bodog FD, Maghiar L, Voiţă-Mekereş F, Lascu CF. A review of social factors affecting women's tendency to cosmetic surgery. Pharmacophore. 2023;14(1):111-5. doi:10.51847/GOEDyJpSvD
- Mekereș F, Voiță GF, Mekereș GM, Bodog FD. Psychosocial impact of scars in evaluation of aesthetic prejudice. Rom J Leg Med. 2017;25:435-8.
- Mekeres GM, Voiţă-Mekereş F, Tudoran C, Buhaş CL, Tudoran M, Racoviţă M, et al. Predictors for estimating scars' internalization in victims with post-traumatic scars versus patients with postsurgical scars. Healthcare (Basel). 2022;10(3):550. doi:10.3390/healthcare10030550
- Voiță-Mekeres F, Buhaș CL, Mekeres GM, Tudoran C, Racovita M, Faur CI, et al. Mekeres' psychosocial internalization scale: A scale for the evaluation of aesthetic prejudice in victims of accidents and violence. Healthcare (Basel). 2021;9(11):1440.
- Paşcalău AV, Cheregi CD, Mureşan MŞ, Şandor MI, Huniadi CA, Nikin Z, et al. CD4+ CD25+ regulatory T-cells role in tumor microenvironment of the squamous cell carcinoma. Rom J Morphol Embryol. 2021;62(1):249-53.
- Tienda-Vázquez MA, Hanel JM, Márquez-Arteaga EM, Salgado-Álvarez AP, Scheckhuber CQ, Alanis-Gómez JR, et al. Exosomes: A promising strategy for repair, regeneration and treatment of skin disorders. Cells. 2023;12(12):1625. doi:10.3390/cells12121625
- Zouboulis CC, Makrantonaki E. Clinical and laboratory skin biomarkers of organ-specific diseases. Mech Ageing Dev. 2019;177:144-9. doi:10.1016/j.mad.2018.08.003
- Visscher MO, Carr AN, Narendran V. Epidermal immunity and function: Origin in neonatal skin. Front Mol Biosci. 2022;9:894496. doi:10.3389/fmolb.2022.894496
- Lee J, Rabbani CC, Gao H, Steinhart MR, Woodruff BM, Pflum ZE, et al. Hair-bearing human skin generated entirely from pluripotent stem cells. Nature. 2020;582(7812):399-404. doi:10.1038/s41586-020-2352-3
- Tudoran C, Tudoran M, Abu-Awwad A, Cut TG, Voiță-Mekereș F. Spontaneous hematomas and deep vein thrombosis during the recovery from a SARS-CoV-2 infection: Case report and literature review. Medicina (Kaunas). 2022;58(2):230. doi:10.3390/medicina58020230
- Mekeres GM, Buhaș CL, Csep AN, Beiușanu C, Andreescu G, Marian P, et al. The importance of psychometric and physical scales for the evaluation of the consequences of scars-A literature review. Clin Pract. 2023;13(2):372-83. doi:10.3390/clinpract13020034
- Goleva E, Berdyshev E, Leung DY. Epithelial barrier repair and prevention of allergy. J Clin Invest. 2019;129(4):1463-74. doi:10.1172/JCI124608
- Mekeres GM, Buhaș CL, Bulzan M, Marian P, Hozan CT. Objective criteria in evaluating the consequences of the posttraumatic scars. Pharmacophore. 2022;13(1):56-61.
- Cavalu S, Simon V, Albon C, Hozan C. Bioactivity evaluation of new silver doped bone cement for prosthetic surgery. J Optoelectron Adv Mater. 2007;9(3):690.
- Wertz P. Epidermal lamellar granules. Skin Pharmacol Physiol. 2018;31(5):262-8. doi:10.1159/000491757
- Nicoara ND, Varga D, Voita-Mekeres F, Galea-Holhos L, Andreescu G, Costas L. Study of basic emotions in the general population using the Likert scale. Pharmacophore. 2023;14(4):14-21. doi:10.51847/tjyOah1VwM
- Voiță-Mekereș F, Voiță GF, Pogan MD, Delcea C, Manole F, Mekereș GM, et al. Clinical considerations of dental longevity from the lateral area. Pharmacophore. 2023;14(3):100-6.
- Alibardi L. General aspects on skin development in vertebrates with emphasis on sauropsids epidermis. Dev Biol. 2023;501:60-73. doi:10.1016/j.ydbio.2023.05.007
- Suman S, Domingues A, Ratajczak J, Ratajczak MZ. Potential clinical applications of stem cells in regenerative medicine. Adv Exp Med Biol. 2019;1201:1-22. doi:10.1007/978-3-030-31206-01
- Chen J, Li S, Li C. Mechanisms of melanocyte death in vitiligo. Med Res Rev. 2021;41(2):1138-66. doi:10.1002/med.21754
- Davidescu L, Chanez P, Ursol G, Korzh O, Deshmukh V, Kuryk L, et al. Late breaking abstract – masitinib in severe asthma: Results from a randomized, phase 3 trial. Eur Respir J. 2020;56(64):4612.
- Agar N, Young AR. Melanogenesis: A photoprotective response to DNA damage? Mutat Res. 2005;571(1-2):121-32.
- Laiho L, Murray JF. The multifaceted melanocortin receptors. Endocrinology. 2022;163(7):bqac083. doi:10.1210/endocr/bqac083
- Rajesh A, Wise L, Hibma M. The role of Langerhans cells in pathologies of the skin. Immunol Cell Biol. 2019;97(8):700-13. doi:10.1111/imcb.12253
- Shigematsu T, Koiwa F, Isaka Y, Fukagawa M, Hagita K, Watanabe YS, et al. Efficacy and safety of upacicalcet in hemodialysis patients with secondary hyperparathyroidism: A randomized placebo-controlled trial. Clin J Am Soc Nephrol. 2023;18(10):1300-9. doi:10.2215/CJN.0000000000000253
- El Genedy-Kalyoncu M, Richter C, Surber C, Blume-Peytavi U, Kottner J. The effect of a basic skin care product on the structural strength of the dermo-epidermal junction: An exploratory, randomised, controlled split-body trial. Int Wound J. 2022;19(2):426-35. doi:10.1111/iwj.13643
- Lacouture ME, Patel AB, Rosenberg JE, O'Donnell PH. Management of dermatologic events associated with the nectin-4-directed antibody-drug conjugate enfortumab vedotin. Oncologist. 2022;27(3):e223-32. doi:10.1093/oncolo/oyac001
- Mekereș GM, Buhaș CL, Tudoran C, Csep AN, Tudoran M, Manole F, et al. The practical utility of psychometric scales for the assessment of the impact of posttraumatic scars on mental health. Front Public Health. 2023;11:1103714. doi:10.3389/fpubh.2023.1103714
- Tan CL, Knight ZA. Regulation of body temperature by the nervous system. Neuron. 2018;98(1):31-48. doi:10.1016/j.neuron.2018.02.022
- Shah A, Tsianou Z, Suchak R, Mann J. Apocrine chromhidrosis. Am J Dermatopathol. 2020;42(10):e147-8. doi:10.1097/DAD.0000000000001712
- Usmani AS. Hair follicle bulb region: A potential nidus for the formation of osteoma cutis. Cutis. 2021;107(1):E31-4. doi:10.12788/cutis.0180
- Passeron T, Lim HW, Goh CL, Kang HY, Ly F, Morita A, et al. Photoprotection according to skin phototype and dermatoses: Practical recommendations from an expert panel. J Eur Acad Dermatol Venereol. 2021;35(7):1460-9. doi:10.1111/jdv.17242
- Shope CN, Andrews LA, Neimy H, Linkous CL, Khamdan F, Lee LW. Characterizing skin cancer in transplant recipients by fitzpatrick skin phototype. Dermatol Ther (Heidelb). 2023;13(1):147-54. doi:10.1007/s13555-022-00858-z
- Coroi MC, Bakraoui A, Sala C, Ţica O, Ţica OA, Jurcă MC, et al. Choroidal melanoma, unfavorable prognostic factors. Case report and review of literature. Roman J Morphol Embryol. 2019;60(2):673-8.
- Holhoș LB, Coroi MC, Lazăr L. Observations on refractive status and risk factors for visual impairment in children with disabilities. Medicina. 2021;57(5):403.
- Lee HJ, Hong YJ, Kim M. Angiogenesis in chronic inflammatory skin disorders. Int J Mol Sci. 2021;22(21):12035. doi:10.3390/ijms222112035
- Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci. 2017;18(3):606. doi:10.3390/ijms18030606
Laverdet B, Danigo A, Girard D, Magy L, Demiot C, Desmoulière A. Skin innervation: Important roles during normal and pathological cutaneous repair. Histol Histopathol. 2015;30(8):875-92. doi:10.14670/HH-11-610