Archive \ Volume.15 2024 Issue 3

The Influence of Physical Factors of the Production Environment on Protein Metabolism in the Body

Markha Suleymanovna Umarova , Zalina Sergeevna Akhyadova , Tanzila Osmanovna Salamanova , Zezag Ilm-Pashaevna Dzhamaldinova , Zukhra Dzhamalayevna Taysumova , Malika Ramzesovna Bekmurzaeva , Madina Magamedovna Tapaeva , Anastasia Maksimovna Ivanushkina*✉

  1. Department of Therapy, Medical Institute, Chechen State University named after A.A. Kadyrov, Grozny, Russia.

  2. Department of Therapy, Medical Institute, Tula State University, Tula, Russia.


Abstract

The negative effect of vibration, as the main physical production factor, should be thoroughly investigated. In this scientific work, the effect of general vibration on protein metabolism in the body is studied using the example of laboratory animals. 2 series of experiments were conducted on 30 white rats kept in the same conditions. At the same time, animals of group 1 were exposed to vibration, unlike animals of group 2. Animals of group 1 were exposed to a general vertical sinusoidal vibration with a frequency of 20 Hz with a vibration velocity of 126 dB for 4 hours daily for 8 weeks. The results of the studies did not reveal significant changes in the total protein content. However, there was a significant decrease in albumin in the content of protein fractions, as well as an increase in the fractions of α- and γ-globulins. It was found that by the end of the experiment, there was a decrease in the content of total amino acids in the blood serum of experimental animals: aspartic acid (P<0.05), proline (P<0.05), glycine (P<0.01), valine (P<0.05), methionine (P<0.05) and phenylalanine (P<0.001). It should be noted that, in general, there is a decrease in the number of hydrophobic (nonpolar) amino acids (valine, proline, phenylalanine, and methionine) and slightly polar uncharged, as well as negatively charged (aspartic acid).


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Vancouver
Umarova MS, Akhyadova ZS, Salamanova TO, Dzhamaldinova ZI, Taysumova ZD, Bekmurzaeva MR, et al. The Influence of Physical Factors of the Production Environment on Protein Metabolism in the Body. Arch Pharm Pract. 2024;15(3):23-7. https://doi.org/10.51847/irgtxJcQcC
APA
Umarova, M. S., Akhyadova, Z. S., Salamanova, T. O., Dzhamaldinova, Z. I., Taysumova, Z. D., Bekmurzaeva, M. R., Tapaeva, M. M., & Ivanushkina, A. M. (2024). The Influence of Physical Factors of the Production Environment on Protein Metabolism in the Body. Archives of Pharmacy Practice, 15(3), 23-27. https://doi.org/10.51847/irgtxJcQcC

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